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June 6, 2026Journal of Drugs in Dermatology

Safety and Effectiveness of Two Reconstitution Volumes of Poly-L-Lactic Acid for Correction of Décolletage Wrinkles

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Authors

JJJohn JosephMPMelanie D. PalmDBDaniel Bråsäter

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Overview

Randomized trial assesses safety and effectiveness of different volumes of PLLA-SCA for décolletage wrinkles, suggesting high patient satisfaction.

Key Points

  • This study aims to evaluate the safety and effectiveness of two different reconstitution volumes of PLLA-SCA for treating décolletage wrinkles.
  • 9-month open-label study with randomization to 8 mL or 17 mL PLLA-SCA reconstitution plus 2% lidocaine
  • Evaluation included GDS, GAIS, skin quality, and adverse events.
  • Participants received up to 4 treatments, spaced 1 month apart.
  • 93.8% of the 8 mL group and 78.6% of the 17 mL group showed ≥1-point improvement on GDS at month 9.
  • Over 90% of subjects reported satisfaction with wrinkle appearance by month 3, sustained throughout the study.
  • Only one adverse event deemed treatment-related, with no serious AEs reported.

Cite This Study

Joseph et al. (2026) studied this question.

synapsesocial.com/papers/6a23b89f71a5da9775e74ccdhttps://doi.org/10.36849/jdd.9928
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