What does this research mean for the field?

Injectable poly-L-lactic acid (PLLA-SCA) is a safe and effective treatment for perioral rejuvenation, yielding positive aesthetic improvements and high patient satisfaction with only mild, transient adverse events. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the aesthetic outcomes and safety profile of poly-L-lactic acid (PLLA-SCA) injectable treatment for perioral rejuvenation.

August 27, 2026CosmeticsOpen Access

Poly-L-Lactic Acid (Sculptra®) for Perioral Rejuvenation: A Case Series

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Authors

APAdrian PalmaCenter for Pediatric Endocrinology Zurich

Discussion

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Implication

Case series demonstrates favorable aesthetic outcomes with poly-L-lactic acid for perioral rejuvenation, indicating a safe and effective biostimulatory treatment option.

Key Points

To describe the aesthetic outcomes and safety profile of poly-L-lactic acid (PLLA-SCA) injectable treatment for perioral rejuvenation.
Retrospective, single-center case series of adults (age ≥ 18 years) with age-associated perioral changes treated with PLLA-SCA as part of full-face rejuvenation.
Reconstituted PLLA-SCA was administered subdermally using a 25-gauge blunt-tip cannula at Baseline, Week 8, and Week 16, with follow-up through Week 28 and monitoring up to 8–13 months.
All patients achieved a Global Aesthetic Improvement Scale score of 'very much improved' or 'much improved' at Week 28, paired with a 5/5 patient-reported satisfaction score.
Treatment produced visible softening of vertical lip lines, restored commissural axis, improved Cupid's bow and vermilion border definition, and refined peri-commissural skin texture while preserving dynamic expression.
Adverse events were restricted to mild, transient bruising and brief edema, with no nodules, delayed-onset reactions, or vascular events observed.

Cite This Study

Adrian Palma (2026) studied this question.

synapsesocial.com/papers/6a8fe9c910c91c1e92621c48 https://doi.org/10.3390/cosmetics13050216

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Implication

Case series demonstrates favorable aesthetic outcomes with poly-L-lactic acid for perioral rejuvenation, indicating a safe and effective biostimulatory treatment option.

Poly-L-Lactic Acid (Sculptra®) for Perioral Rejuvenation: A Case Series

Discussion

Member takes

Implication

Key Points

Cite This Study

Poly-L-Lactic Acid (Sculptra®) for Perioral Rejuvenation: A Case Series

Discussion

Member takes

Implication

Key Points

Cite This Study

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