What does this research mean for the field?

A modified poly-L-lactic acid (PLLA) filler safely and effectively improves infraorbital hollowing and periorbital skin quality in patients with moderate-to-severe periorbital aging. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the efficacy and safety of poly‐L‐lactic acid (PLLA) filler for enhancing periorbital aesthetics.

June 6, 2026Journal of Cosmetic DermatologyOpen Access

Efficacy and Safety of a Modified Poly‐L‐Lactic Acid Filler for Periorbital Rejuvenation: A Prospective, Single‐Arm Clinical Study

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To evaluate the efficacy and safety of poly‐L‐lactic acid (PLLA) filler for enhancing periorbital aesthetics.
Prospective single-arm clinical study with 30 subjects having moderate-to-severe infraorbital hollowing.
Subjects received three PLLA injections at 4-week intervals and were assessed at multiple follow-ups up to 24 weeks after treatment.
Efficacy was primarily evaluated using the Allergan Infraorbital Hollows Scale (AIHS) and supported by 3D imaging assessments.
At 24 weeks, 86.7% of subjects achieved at least a 1-grade improvement in AIHS bilaterally (95% CI, 70.3%–94.7%).
Wrinkle scores and black area significantly decreased, while hemoglobin area increased at multiple time points post-treatment.
All subjects reported an aesthetic improvement, with no severe complications noted.

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Implication

Prospective clinical study demonstrates improved skin quality in subjects with infraorbital hollowing, indicating potential benefits of PLLA filler treatment.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a23ba3c71a5da9775e75f18 https://doi.org/10.1111/jocd.70953

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Implication

Prospective clinical study demonstrates improved skin quality in subjects with infraorbital hollowing, indicating potential benefits of PLLA filler treatment.

Efficacy and Safety of a Modified Poly‐L‐Lactic Acid Filler for Periorbital Rejuvenation: A Prospective, Single‐Arm Clinical Study

Key Points

Discussion

Implication

Cite This Study

Efficacy and Safety of a Modified Poly‐L‐Lactic Acid Filler for Periorbital Rejuvenation: A Prospective, Single‐Arm Clinical Study

Key Points

Discussion

Implication

Cite This Study

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