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This is a Human Clinical Trial study.

Combination Therapy With Poly D–L Lactic Acid and Autologous Fat Transplantation for Infraorbital Rejuvenation

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Patients experienced significant improvement in infraorbital hollowing, effectively rejuvenating the under-eye area.
All patients were treated with a combination of poly d l lactic acid and autologous fat, with improvements noted in skin quality.
Treatment involved dermal injection and systematic multilayer fat transfer across various follow-up periods.
This technique highlights the potential for superior patient satisfaction and safety compared to traditional treatments.

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Combination therapy enhances skin quality and fat retention in patients with infraorbital hollowing, indicating improved outcomes.

Earl et al. (2025) studied this question.

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