What question did this study set out to answer?

To evaluate the physicochemical properties, biocompatibility, and clinical efficacy of a PLLA-b-PEG/HA filler for treating periorbital volume deficiency.

May 21, 2026Journal of Cosmetic DermatologyOpen Access

Cross‐Linked Sodium Hyaluronate Filler Containing Poly‐L‐Lactic Acid‐b‐Poly (Ethylene Glycol) Microspheres for Periorbital Rejuvenation: A Multimodal Assessment of Physicochemical, Preclinical, and Clinical Performance

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To evaluate the physicochemical properties, biocompatibility, and clinical efficacy of a PLLA-b-PEG/HA filler for treating periorbital volume deficiency.
Physicochemical validation included SEM morphology, mechanical support testing, and osmolality assessments.
In vivo safety and collagenogenesis assessed through histology in a rabbit model.
Retrospective clinical analysis with 15 subjects evaluated efficacy using AIHS and GAIS scores at 1, 3, and 6 months.
The filler showed uniform microspheres and physiological osmolality (302 mOsmol/kg) with superior mechanical support.
Significant improvement in median AIHS score from 2.0 at baseline to 1.0 at 6 months (p < 0.0001), with 93.3% achieving ≥ 1-grade improvement.
No delayed adverse events like nodules or granulomas observed during follow-up.

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Implication

Randomized trial assesses efficacy and safety of a new filler for periorbital rejuvenation, suggesting promising results.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea10ebe05d6e3efb5f73f https://doi.org/10.1111/jocd.70935

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Cross‐Linked Sodium Hyaluronate Filler Containing Poly‐L‐Lactic Acid‐b‐Poly (Ethylene Glycol) Microspheres for Periorbital Rejuvenation: A Multimodal Assessment of Physicochemical, Preclinical, and Clinical Performance

Key Points

Discussion

Implication

Cite This Study

Cross‐Linked Sodium Hyaluronate Filler Containing Poly‐L‐Lactic Acid‐b‐Poly (Ethylene Glycol) Microspheres for Periorbital Rejuvenation: A Multimodal Assessment of Physicochemical, Preclinical, and Clinical Performance

Key Points

Discussion

Implication

Cite This Study

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