What question did this study set out to answer?

To assess the efficacy and safety of Poly-L-Lactic Acid (PLLA) filler for treating temple hollowing.

Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study

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To assess the efficacy and safety of Poly-L-Lactic Acid (PLLA) filler for treating temple hollowing.
Randomized, evaluator-blinded, multicenter clinical trial
Enrolled 174 participants with moderate to severe temple hollowing
Treatment group received 2 to 3 sessions of PLLA injections with 12-month follow-up
Control group received no treatment for 6 months
Efficacy evaluated using multiple scales and reported satisfaction
96.5% of the treatment group showed at least 1-grade improvement on the Allergan Temple Hollowing Scale at 6 months vs. 0% in control (P < 0.0001)
Significant improvements in all secondary endpoints, including GAIS and temporal volume measurements
Aesthetic improvement and participant satisfaction were consistently high at all follow-ups
PLLA showed excellent safety with no therapy-related adverse events reported

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Randomized trial evaluates the effectiveness of PLLA filler for enhancing temple hollowing, indicating significant aesthetic improvements.

Chang et al. (2026) studied this question.

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Randomized trial evaluates the effectiveness of PLLA filler for enhancing temple hollowing, indicating significant aesthetic improvements.