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December 2, 2025Journal of Clinical InvestigationOpen Access

Longitudinal multi-omic signatures of ARDS and sepsis inflammatory phenotypes identify pathways associated with mortality

Kim Bardillon Sidney Carrillo Kirsten N. Kangelaris Kathleen D. Liu Emma Schmiege Kathryn Sullivan Michael A. Matthay

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Key Points

Sepsis inflammatory phenotypes correlate with increased mortality during longitudinal observation, highlighting risk factors.
The study found mortality linked to specific pathways associated with sepsis, emphasizing targeted treatment needs.
Analysis utilized longitudinal multi-omic data to identify critical signatures in the inflammatory response to sepsis.
Understanding these pathways may inform more effective clinical strategies for managing sepsis and improving outcomes.

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Implication

Longitudinal analysis shows associations between sepsis inflammatory phenotypes and mortality, indicating potential intervention pathways.

Abstract

This work is the result of NIH funding.

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Cite This Study

Bardillon et al. (2025) studied this question.

synapsesocial.com/papers/69337ce8b3f947a0a125a159 https://doi.org/10.1172/jci196290

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1C55-10 The Emerging Role of Multiomics in Phenotyping and Personalized Therapy for Acute Respiratory Distress Syndrome (ARDS): A Systematic Reviewsystematic_review · 2026
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4Heterogeneity of immune cells and their communications unveiled by transcriptome profiling in acute inflammatory lung injury2024 · 22 citations
5Identification and exploration of novel biomarkers and potential therapeutic agents for the progression of sepsis to septic ARDS2025

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