Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025MedicineOpen Access

Identification and exploration of novel biomarkers and potential therapeutic agents for the progression of sepsis to septic ARDS

View Full Paper
Ask AI
Bookmark
Share

Authors

HCHu ChenUnion HospitalTDTing DuMcGill University Health CentreMLMei LiuShandong University of Traditional Chinese Medicine

Discussion

Loading...

Member takes

Overview

This analysis uncovers biomarkers and therapeutic approaches for ARDS in sepsis patients, suggesting new avenues for treatment.

Key Points

  • A diagnostic nomogram was created using three hub genes, showing ideal performance for identifying septic ARDS.
  • Analysis identified 49 key genes related to sepsis and ARDS, highlighting pathways involved in immune dysregulation.
  • Gene expression data from the Gene Expression Omnibus database supported the findings, emphasizing the role of inflammatory responses.
  • A potential therapeutic agent, etoposide, was proposed based on connectivity map analysis, indicating new treatment strategies.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa35chttps://doi.org/10.1097/md.0000000000044170
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of cellular senescence genes and Immune Infiltration in sepsis and sepsis-induced ARDS based on bioinformatics analysis2024
  2. 2Identification of biomarkers associated with coagulation and fibrinolysis in acute respiratory distress syndrome caused by sepsis based on bioinformatics2024
  3. 3Identification and validation of potential shared diagnostic markers for sepsis-induced ARDS and cardiomyopathy via WGCNA and machine learning2025
  4. 4The role of angiogenesis-related genes in sepsis-induced acute respiratory distress syndrome2024
  5. 5Identification and analysis of the endoplasmic reticulum stress hub genes in sepsis-associated ARDS2025 · 6 citations