Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025MedicineOpen Access

Identification and exploration of novel biomarkers and potential therapeutic agents for the progression of sepsis to septic ARDS

View Full Paper
Ask AI
Bookmark
Share

Authors

HCHu ChenTDTing DuMLMei Liu

Discussion

Loading...

Member takes

Overview

This analysis uncovers biomarkers and therapeutic approaches for ARDS in sepsis patients, suggesting new avenues for treatment.

Key Points

  • A diagnostic nomogram was created using three hub genes, showing ideal performance for identifying septic ARDS.
  • Analysis identified 49 key genes related to sepsis and ARDS, highlighting pathways involved in immune dysregulation.
  • Gene expression data from the Gene Expression Omnibus database supported the findings, emphasizing the role of inflammatory responses.
  • A potential therapeutic agent, etoposide, was proposed based on connectivity map analysis, indicating new treatment strategies.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa35chttps://doi.org/10.1097/md.0000000000044170
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles2005 · 58,122 citations
  2. 2The suppressive effects of Mer inhibition on inflammatory responses in the pathogenesis of LPS-induced ALI/ARDS2022 · 57 citations
  3. 3Predicting candidate therapeutic drugs for sepsis-induced acute respiratory distress syndrome based on transcriptome profiling2021 · 8 citations
  4. 4Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis2023 · 8 citations
  5. 5Diverse macrophage populations mediate acute lung inflammation and resolution2014 · 594 citations