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September 10, 2025Scientific ReportsOpen Access

Identification and analysis of the endoplasmic reticulum stress hub genes in sepsis-associated ARDS

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Authors

LGLing GaoShanxi Academy of Medical SciencesTLTingting LiuShanxi Academy of Medical SciencesXLXiaoyan LiFujian Medical University

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Overview

Bioinformatics reveals hub genes related to endoplasmic reticulum stress in ARDS from sepsis, suggesting diagnostic potential.

Key Points

  • Five hub genes were identified, with STAT3 significantly upregulated and YWHAQ downregulated in sepsis-associated ARDS compared to healthy controls.
  • Using three machine learning algorithms, the study evaluated the diagnostic performance of hub genes, confirming their clinical utility in ARDS.
  • A total of 438 differentially expressed genes were identified, highlighting key biological processes involved in sepsis-related ARDS.
  • Functional enrichment and immune cell infiltration analyses were integrated to better understand the role of endoplasmic reticulum stress in ARDS.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68c1d03554b1d3bfb60f6c70https://doi.org/10.1038/s41598-025-16644-8
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