LINC02878/ZNF282/PYCR2 axis promotes proline synthesis and tumor progression in colorectal cancer

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Oncogenic lncRNA LINC02878 increases tumor growth and metastasis in colorectal cancer, suggesting new therapeutic targets.

Tumor growth is significantly enhanced, indicating a critical role of the LINC02878/ZNF282/PYCR2 axis in colorectal cancer.
LINC02878 correlates with poor prognosis in colorectal cancer patients, with lncRNA knockdown reducing tumor size by promoting proline biosynthesis.
Analysis in xenograft models demonstrates reduced lung metastasis and improved survival following LINC02878 knockdown treatments.
These findings highlight the potential for targeting the LINC02878 pathway to develop therapeutic interventions against colorectal cancer.

Lei et al. (2025) studied this question.

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