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December 6, 2025Journal of Translational Medicine3 citationsOpen Access

Single-cell transcriptomic profiling reveals aberrant CD4⁺ naive T cell differentiation driving immune activation in Behçet’s uveitis

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YLYunfei Liu

Key Points

  • Dysregulated T cell differentiation drives immune activation in Behçet’s uveitis, leading to inflammation.
  • Key insights suggest a coordinated immune response influencing ocular inflammation.
  • Assessment utilizing single-cell transcriptomic profiling highlights critical pathways in immune modulation.
  • These findings emphasize potential therapeutic targets for managing immune dysregulation and preventing damage.

Abstract

Our study reveals a coordinated mechanism linking systemic T cell dysregulation to localized ocular inflammation in BU. Targeting IL-32 and CXCR4 may represent promising strategies for restoring immune balance and preventing tissue damage in BU.

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Cite This Study

Yunfei Liu (2025) studied this question.

synapsesocial.com/papers/69337cefb3f947a0a125a347https://doi.org/10.1186/s12967-025-07520-0
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