Heterologous Biosynthetic Crosstalk with the Native Mansouramycin Cluster in Streptomyces albus Del14 Reveals Unexpected Metabolites

Marc Stierhof; Liliya Horbal; Paul Alan Cox

doi:10.1039/d5cb00235d

January 1, 2025RSC Chemical BiologyOpen Access

Heterologous Biosynthetic Crosstalk with the Native Mansouramycin Cluster in Streptomyces albus Del14 Reveals Unexpected Metabolites

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Key Points

Unexpected metabolites were revealed through heterologous crosstalk in biosynthetic clusters.
The study focuses on natural product discovery in the Streptomyces genus, particularly Streptomyces albus.
This analysis employed biosynthetic gene clusters to explore unique metabolic pathways.
The findings may highlight significant potential for future antibiotic development and natural product research.

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Implication

Analysis shows heterologous biosynthetic crosstalk reveals novel metabolites in Streptomyces, suggesting new avenues for discovery.

Abstract

Streptomyces albus J1074 (now S. albidoflavus J1074) is a widely used heterologous host for natural product discovery due to its capacity to express biosynthetic gene clusters (BGCs) from diverse organisms....

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Stierhof et al. (2025) studied this question.

synapsesocial.com/papers/69337cfbb3f947a0a125a566 https://doi.org/10.1039/d5cb00235d

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Heterologous Biosynthetic Crosstalk with the Native Mansouramycin Cluster in Streptomyces albus Del14 Reveals Unexpected Metabolites

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Heterologous Biosynthetic Crosstalk with the Native Mansouramycin Cluster in Streptomyces albus Del14 Reveals Unexpected Metabolites

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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