September 11, 2025

as a versatile host platform for heterologous production of microbial natural products.

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Review demonstrates trends in heterologous expression of biosynthetic gene clusters in Streptomyces, highlighting implications for natural products.

Heterologous expression significantly influences natural product discovery, enhancing access to silent biosynthetic pathways.
The review analyzes over 450 peer-reviewed studies, with a focus on trends in biosynthetic gene clusters and host preferences.
Streptomyces serves as a versatile platform for expressing microbial natural products, aided by synthetic biology tools and genome engineering.
Insights into genomic integration and regulatory strategies help address barriers in the production of complex metabolites.

Lasch et al. (2025) studied this question.

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Review demonstrates trends in heterologous expression of biosynthetic gene clusters in Streptomyces, highlighting implications for natural products.