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Custom platform demonstrates electrophysiology in brain and heart organoids, implying stable recording conditions are effective.
We present a custom recording platform that enables electrophysiological recordings with Neuropixels 2.0 from human brain and heart organoids by maintaining a stable, physiological environment of 5% CO2, 37 °C, and 95% relative humidity. The platform combines a modular positioning system with real-time camera guidance for precise probe alignment. We validated the system by recording consistent bursting activity in brain organoids over a 110-min period and in heart organoids for up to 11 h.
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Sala‐Jarque et al. (2025) studied this question.
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