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December 4, 2025Frontiers in PharmacologyOpen Access

The PI3K/AKT/mTOR pathway in scar remodeling and keloid formation: mechanisms and therapeutic perspectives

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Key Points

Keloids and hypertrophic scars arise from dysregulation of fibroblast activity, leading to excessive extracellular matrix deposition.
Key findings indicate targeting the PI3K/AKT/mTOR pathway could enhance therapeutic strategies for keloid and hypertrophic scar treatments.
Review assesses current knowledge and novel small-molecule inhibitors in regulating collagen synthesis and cellular pathways.
Understanding the PI3K/AKT/mTOR signaling may provide a foundation for future therapeutic interventions against aberrant scarring.

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Implication

This review showcases dysregulation in the PI3K/AKT/mTOR pathway and highlights therapeutic strategies targeting collagen synthesis and pathogenesis.

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Cite This Study

Shengbin Qi (2025) studied this question.

synapsesocial.com/papers/693624984fa91c937236c20e https://doi.org/10.3389/fphar.2025.1678953

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