December 8, 2025Frontiers in ImmunologyOpen Access

Temporal dynamics of IgG-mediated immunometabolic dysfunction: from acute obesity to chronic aging

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Discussion

Review highlights IgG's contribution to metabolic disease in obesity and aging, indicating potential biomarkers and therapeutic targets.

IgG dysfunction is linked to obesity and aging, influencing immune responses and insulin resistance.
Sialylated IgG promotes anti-inflammatory pathways, while hyposialylated IgG activates pathways leading to insulin resistance.
Analysis of glycosylation patterns may aid in identifying insulin-sensitive versus insulin-resistant individuals.
Identifying therapeutic targets like FcRn antagonists may improve treatment efficacy for metabolic diseases.

Jung-Hyun Kim (2025) studied this question.

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