December 8, 2025Frontiers in MedicineOpen Access

CT-integrated pathophysiology-guided, clinically causal cognition-led interpretable lesion context characterization and risk reasoning in lung MWA

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Discussion

Analytical framework enhances causal-consistency for pneumothorax and hemorrhage risks in non-small cell lung cancer microwave ablation.

The framework improved risk reasoning for pneumothorax and hemorrhage in patients undergoing microwave ablation.
Multi-task AUCs reached 0.903 for pneumothorax and 0.871 for hemorrhage in 184 cases analyzed.
Post-hoc lesion-context graph enhanced interpretable lesion-context characterization through causal frameworks.
Causal-consistency metrics indicated expected risk changes with anatomical relationship integrity maintained.

Li et al. (2025) studied this question.

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