Sex differences in reward network activation are linked to problematic substance use among high-risk adolescents

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Higher modulated brain activation in females during risky choices indicates lower problematic substance use risk.
Neuroimaging highlights different brain activation patterns in youth with attention-deficit/hyperactivity disorder and conduct disorder.
Cox proportional hazards models reveal significant sex differences in associations with substance use disorders.
Findings emphasize the necessity for targeted research on sex differences in substance use prevention strategies.

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Neuroimaging research shows sex differences in brain activation during risky decisions in youth, implying links to substance use disorders.

Murray et al. (2025) studied this question.

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Neuroimaging research shows sex differences in brain activation during risky decisions in youth, implying links to substance use disorders.