This review discusses developments in targeted protein degradation methods, highlighting PROTACs' effectiveness against drug-resistant microorganisms using nanoparticles and exosomes.
Key Points
Targeted protein degradation shows promise in tackling antimicrobial resistance through novel strategies.
Recent advancements in PROTAC technology focus on effective delivery options, including nanoparticles and exosomes.
E3 ligase selection and linker design are crucial factors influencing the success of protein degradation strategies.
This approach may provide viable alternatives to traditional drug therapies in overcoming drug resistance challenges.