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This review discusses developments in targeted protein degradation methods, highlighting PROTACs' effectiveness against drug-resistant microorganisms using nanoparticles and exosomes.
Targeted protein degradation (TPD) is an innovative therapeutic approach that bypasses traditional drug inhibition methods. Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that harness degradation machinery to remove target proteins. This review examines the evolution of PROTACs and their application in targeting microorganisms that develop drug resistance, covering their development, advancements in linker design, E3 ligase selection, and delivery methods, including nanoparticles and exosomes.
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Sarwan et al. (2025) studied this question.
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