Optimized Magnetic Resonance T1 Mapping for Estimation of Intrathecal Contrast Concentrations in Human Brain and Ventricular Cerebrospinal Fluid

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An optimized Look‐Locker T1 mapping protocol enabled estimation of gadobutrol concentrations.
The phantom study confirmed repeatability in measuring cerebrospinal fluid T1 relaxation times.
Using a 3 T MRI scanner, the method showed feasibility in patients with normal pressure hydrocephalus.
Optimizing T1 mapping addresses challenges in accurately determining tracer concentrations in the human brain.

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Optimized MRI protocol estimates gadobutrol concentrations in cerebrospinal fluid, indicating its role in assessing glymphatic function.

Valnes et al. (2025) studied this question.

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