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December 8, 2025Future Journal of Pharmaceutical SciencesOpen Access

Synthesis and anti-inflammatory, analgesic, and anti-ulcerogenic bioevaluation of new indole bioconjugates

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Authors

VRV. Krishna ReddyVBVasudha Bakshi

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Overview

New indole bioconjugates demonstrate significant anti-inflammatory and analgesic effects, suggesting potential as therapeutic agents.

Key Points

  • Compounds showed significant anti-inflammatory activity, with some achieving over 91% ulcer inhibition rates.
  • Binding affinities calculated via molecular docking for target compounds against hCOX-2 correlate with pharmacological activities.
  • Analgesic and anti-ulcer activities of synthesized compounds were assessed using established in vivo models and scored accordingly.
  • These findings highlight the therapeutic potential of the synthesized indole bioconjugates, particularly against gastrointestinal side effects.

Cite This Study

Reddy et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c3eehttps://doi.org/10.1186/s43094-025-00905-4
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