March 15, 2024MoleculesOpen Access

Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

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Novel phenoxy acetic acid derivatives selectively inhibited the COX-2 enzyme without causing gastric ulcers, reducing acute inflammatory responses in animal models.
Biological evaluation showed compound 5f reduced paw thickness by 63.35% and lowered PGE-2 by 60.58%, demonstrating marked anti-inflammatory efficacy in vivo.
Supports developing selective COX-2 inhibitors to block prostaglandins in inflammatory conditions; rodent model, further preclinical work needed to evaluate safety.

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Implication

In vivo evaluation shows potent anti-inflammatory activity of novel phenoxy acetic acid derivatives in animal models, highlighting selective COX-2 inhibition without gastric ulceration.

Cite This Study

Alshaye et al. (2024) studied this question.

synapsesocial.com/papers/68e73cbeb6db6435876b6368 https://doi.org/10.3390/molecules29061309

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Implication

In vivo evaluation shows potent anti-inflammatory activity of novel phenoxy acetic acid derivatives in animal models, highlighting selective COX-2 inhibition without gastric ulceration.

Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

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Discussion

Implication

Cite This Study

Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

Key Points

Discussion

Implication

Cite This Study

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