Divergent Synthesis of Spiro or Fused Indole Derivatives Tethered with Seven-Membered Rings

Zongkang Wang; Lan Tu; Yawen Lan; Yan Wang; Peng He; Na-na Fei; Yakun Jiang; Chengyu Wang; Yanzhong Li

doi:10.1039/d5qo01405k

December 4, 2025Organic Chemistry Frontiers

Divergent Synthesis of Spiro or Fused Indole Derivatives Tethered with Seven-Membered Rings

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Key Points

Divergent synthesis leads to spiro indolines tethered with seven-membered rings.
Selectfluor yielded good to excellent results in the synthesis process.
This observational analysis presents a novel approach to indole derivatives.
These findings suggest potential applications in advanced organic synthesis.

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Implication

Divergent synthesis produces spiro indolines with selectfluor in good yields, suggesting improved methods for complex molecules.

Abstract

An efficient divergent synthesis of spiro[furan-2,2'-indolines] fused with seven-membered rings and cyclopenta[b]indoles tethered with 7-oxabicyclo[4.1.1]octanes is described. Spiro[furan-2,2'-indolines] fused with seven-membered rings were obtained with selectfluor in good to excellent...

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Wang et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c441 https://doi.org/10.1039/d5qo01405k

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Divergent Synthesis of Spiro or Fused Indole Derivatives Tethered with Seven-Membered Rings

Key Points

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Implication

Abstract

Discussion

Cite This Study

Divergent Synthesis of Spiro or Fused Indole Derivatives Tethered with Seven-Membered Rings

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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