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February 14, 2026The Journal of Organic Chemistry

Synthesis of SpiroIndane-1,3-Dione-2-Pyrrolidines by the Reaction of 2-(2′-Ketoalkyl)-1,3-Indandiones with Triazinanes

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Authors

BPBiman PalSSSusmita SahooSMSahil Mondal

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Overview

Demonstrates a novel method to synthesize spirocyclic compounds, suggesting wide applications in medicinal chemistry.

Key Points

  • The research aims to create a new method for synthesizing spiro[indane-1,3-dione-2-pyrrolidines] using specific chemical reactions.
  • Utilized a transition metal-free synthesis approach.
  • Reacted 2-(2'-ketoalkyl)-1,3-indandiones with triazinanes.
  • Tested various drug molecules and chiral amines for versatility.
  • Achieved good to excellent yields of spirocyclic products.
  • Successfully incorporated a range of drug molecules in the synthesis.
  • Demonstrated potential applications in medicinal and synthetic organic chemistry.

Cite This Study

Pal et al. (2026) studied this question.

synapsesocial.com/papers/699011932ccff479cfe584eahttps://doi.org/10.1021/acs.joc.5c02934
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