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September 5, 2025RSC AdvancesOpen Access

DABCO-catalysed highly diastereoselective synthesis of 1,3-indandione containing fully saturated spirocyclopentanes involving 2-(2′-ketoalkyl)-1,3-indandiones and nitrostyrenes

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Authors

GMGitanjali MishraMBMissa Saril BobongaKIKamrul Islam

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Overview

Study demonstrates DABCO-catalysed diastereoselective synthesis of 1,3-indandiones with nitrostyrenes, highlighting the formation of multiple chiral centres.

Key Points

  • The synthesis yields highly functionalized 1,3-indandiones with three consecutive chiral centres and a spirocyclic centre.
  • Products are formed with significant diastereoselectivity when using DABCO as a catalyst in the reaction with nitrostyrenes.
  • The process involves a reaction between nitrostyrenes and 2-(2'-ketoalkyl)-1,3-indandiones, emphasizing the role of DABCO.
  • This method may facilitate more efficient syntheses of complex molecular architectures in organic chemistry.

Cite This Study

Mishra et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc956400https://doi.org/10.1039/d5ra04224k
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