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December 8, 2025Journal of Cellular Physiology

Lactobacillus acidophilus Ameliorates Inflammatory Bone Loss Under Postmenopausal Osteoporotic Conditions via Modulating the Gut‐Resident RORγT − pTreg Cell Population

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Authors

ABAsha BhardwajLSLeena SapraCSChaman Saini

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Overview

Observational analysis reveals Lactobacillus acidophilus restores balance of Th17 cells and Foxp3 in postmenopausal osteoporosis, suggesting probiotic potential.

Key Points

  • Lactobacillus acidophilus was found to restore the balance of Th17 cells in postmenopausal osteoporosis.
  • The restoration is associated with modulation of the Foxp3 + Tregs population following supplementation.
  • Immune system alterations during inflammatory conditions are pivotal in postmenopausal osteoporosis development.
  • The research indicates potential for Lactobacillus acidophilus as a novel probiotic in bone health management.

Cite This Study

Bhardwaj et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c480https://doi.org/10.1002/jcp.70114
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics2016 · 637 citations
  2. 2Immunoporosis: Immunology of Osteoporosis—Role of T Cells2018 · 328 citations
  3. 3High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice2018 · 86 citations
  4. 4Mechanisms of exTreg induction2021 · 53 citations