What is the clinical evidence from this study?

Study design: Review. Population: Pulmonary hypertension. Intervention: Pericytes.

What type of study is this?

This is a Literature Review study.

December 8, 2025Arteriosclerosis Thrombosis and Vascular Biology

Pericytes and Lung Vascular Remodeling

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Key result

Pericytes drive vascular remodeling in pulmonary hypertension, with Higd1b emerging as a novel specific marker.

Design

Review

Authors

MMM. Elizabeth Moss MSMarisa C Smit TKTimothy Klouda

Discussion

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Implication

This review highlights the increasingly recognized role of pericytes in pulmonary hypertension pathobiology and their potential as novel therapeutic targets.

Key Points

Pericytes significantly impact vascular remodeling in pulmonary hypertension, leading to potential therapeutic insights.
The review identifies mechanisms like transforming growth factor-β and Wnt5a in pericyte function related to vascular diseases.
Analysis of recent single-cell RNA sequencing data sheds light on novel pericyte markers and subtypes.
Understanding pericyte morphology and function may unlock new strategies for treating pulmonary hypertension.

PICO

Population

Pulmonary hypertension

Intervention / Comparator

Pericytes

This review highlights the increasingly recognized role of pericytes in pulmonary hypertension pathobiology and their potential as novel therapeutic targets.

Cite This Study

Moss et al. (2025) conducted a review in Pulmonary hypertension. Pericytes was evaluated. Pericytes play a critical role in pulmonary hypertension vascular remodeling, with recent single-cell RNA sequencing identifying Higd1b as a novel specific marker to improve their identification.

synapsesocial.com/papers/693624ad4fa91c937236c587 https://doi.org/10.1161/atvbaha.125.322518

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December 8, 2025Arteriosclerosis Thrombosis and Vascular Biology

Pericytes and Lung Vascular Remodeling

View Full Paper

Ask AI

Bookmark

Key result

Pericytes drive vascular remodeling in pulmonary hypertension, with Higd1b emerging as a novel specific marker.

Design

Review

Authors

MMM. Elizabeth Moss MSMarisa C Smit TKTimothy Klouda

Discussion

Member takes

Implication

This review highlights the increasingly recognized role of pericytes in pulmonary hypertension pathobiology and their potential as novel therapeutic targets.

Key Points

Pericytes significantly impact vascular remodeling in pulmonary hypertension, leading to potential therapeutic insights.
The review identifies mechanisms like transforming growth factor-β and Wnt5a in pericyte function related to vascular diseases.
Analysis of recent single-cell RNA sequencing data sheds light on novel pericyte markers and subtypes.
Understanding pericyte morphology and function may unlock new strategies for treating pulmonary hypertension.

PICO

Population

Pulmonary hypertension

Intervention / Comparator

Pericytes

This review highlights the increasingly recognized role of pericytes in pulmonary hypertension pathobiology and their potential as novel therapeutic targets.

Cite This Study

synapsesocial.com/papers/693624ad4fa91c937236c587 https://doi.org/10.1161/atvbaha.125.322518

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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