Molecular mechanisms of the lysosomal damage response and its roles in aging and disease

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains2025
2. 2Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells.1990 · 280 citations
3. 3TECPR1 is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagy2023 · 79 citations
4. 4In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair2022 · 65 citations