Findings reveal reduced oxidative stress and ECM accumulation in glomerular mesangial cells, indicating Vitamin D3's protective role against kidney damage.
1,25(OH)₂D₃ confers renoprotection in DN by inhibiting the ROS/TXNIP/NLRP3 inflammasome axis, thereby suppressing oxidative stress, inflammatory cytokine production, ECM accumulation, and pyroptotic cell death in glomerular mesangial cells and renal tissues.
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Meng et al. (2025) studied this question.
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