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December 8, 2025Annals of the New York Academy of SciencesOpen Access

Globus Pallidus Iron Relates to Cognitive Impairment in Alzheimer's Disease: Evidence From MRI‐Based Meta‐Analysis

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Authors

MMMarthe Mieling

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Overview

Meta-analysis demonstrates higher iron in basal ganglia correlating with cognitive impairment in Alzheimer's disease, suggesting neurobiological implications.

Key Points

  • Cognitive impairment correlates with increased iron levels in Alzheimer's disease patients, especially in basal ganglia.
  • Meta-analysis of 23 MRI experiments involved 715 Alzheimer's disease patients and 1130 healthy controls.
  • Assessment used Mini-Mental-Status-Examination for cognitive performance across specified brain regions.
  • Highlights that increased iron levels may impact cognitive function, reinforcing the need for further investigation.

Cite This Study

Marthe Mieling (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c7abhttps://doi.org/10.1111/nyas.70078
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