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December 8, 2025Journal of Pineal ResearchOpen Access

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications

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Authors

ŁKŁukasz Konecki

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Overview

This review reveals melatonin’s potential to improve treatment of gastrointestinal cancers, suggesting clinical implications and the need for preclinical evidence.

Key Points

  • Melatonin shows a significant therapeutic potential for gastrointestinal cancers, enhancing the efficacy of treatment methods.
  • Notably, tumor volume was reduced by 70% in preclinical studies using melatonin alongside chemoradiotherapy.
  • Clinical implications warrant exploration of melatonin's molecular mechanisms, including its effect on reactive oxygen species and circadian rhythms.
  • Future research should aim for standardized dosing and assess biomarkers to enhance treatment efficacy, given melatonin’s low toxicity.

Cite This Study

Łukasz Konecki (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236c7e2https://doi.org/10.1111/jpi.70101
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