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December 8, 2025Cancer Research

Abstract B035: Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia

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Authors

SMSadegh MarzbanCGCurtis GravenmierLZLing Zhang

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Overview

Analysis reveals dedifferentiation drives chemotherapy resistance in B-lymphoblastic leukemia, suggesting new therapy targets.

Key Points

  • To investigate how cell state transitions affect disease progression and resistance in B-lymphoblastic leukemia.
  • Analyzed flow cytometry data from bone marrow and peripheral blood samples of B-ALL patients.
  • Defined major cell states and quantified transition rates using continuous-time Markov chain modeling.
  • Applied machine learning techniques like linear discriminant analysis to predict clinical outcomes.
  • In remission, differentiation rates exceeded dedifferentiation rates, indicating normal lineage progression.
  • In relapse, dedifferentiation often dominated, leading to the rebuilding of stem-like compartments.
  • Inhibiting dedifferentiation produced sustained depletion of resistant stem-like cells.

Cite This Study

Marzban et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf6chttps://doi.org/10.1158/1538-7445.canevol25-b035
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia2025 · 2 citations
  2. 2Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia2025
  3. 3Alternating cycles of quiescent and proliferative cell states determine stemness and leukemia-initiation capacity in acute lymphoblastic leukemia2025
  4. 4Abstract 2307: State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia (CML)2024 · 1 citations
  5. 5Abstract 4758: MYC-BCL6 state transition drives metabolomic cycling and leukemia-initiating capacity in B-ALL2026