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December 8, 2025Cancer Research

Abstract B032: Integrated genomic analysis defines early and late drivers of glioma evolution and survival outcome in GBM

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Authors

HKHarpreet KaurKCKevin CamphausenUSUma Shankavaram

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Overview

Integrated genomic analysis identifies key mutations in glioma, revealing survival differences in patients with distinct TP53 status.

Key Points

  • This research analyzes the role of specific mutations and co-mutations in glioma progression and their impact on patient survival.
  • Genomic and clinical data analyzed from TCGA and MSKCC cohorts
  • Mutational profiling and driver analysis conducted using maftools
  • Survival analysis performed with survival and survminer tools
  • Pathway-level disruptions assessed across tumor grades
  • Grade-wise analysis revealed distinct evolutionary trajectories in glioma progression
  • Lower-grade gliomas showed mutations in IDH1, TP53, and ATRX, while GBM had late oncogenic events like EGFR and PIK3CA
  • Long-term survivors linked to favorable mutations in ATRX, IDH1, and TP53, whereas poor outcomes correlated with other mutations

Cite This Study

Kaur et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf6ehttps://doi.org/10.1158/1538-7445.canevol25-b032
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