What question did this study set out to answer?

This study aims to evaluate the relationship between area-level socioeconomic factors and survival in older adults with acute myeloid leukemia (AML).

December 8, 2025BloodOpen Access

Area deprivation index as a predictor of survival and treatment disparities in older adults with Acute Myeloid Leukemia: A population-based Study

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Authors

VTValerie TranUniversity of Virginia APAsal PilehvariUniversity of Virginia Health System NBNadia M. BambaceBaptist Hospital of Miami

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Implication

Population-based study shows area deprivation index predicts worse survival and treatment disparities in older adults with acute myeloid leukemia, indicating socioeconomic factors impact care.

Key Points

This study aims to evaluate the relationship between area-level socioeconomic factors and survival in older adults with acute myeloid leukemia (AML).
Used SEER-Medicare claims data to identify patients aged 66 and older diagnosed with AML.
Linked area deprivation index and social vulnerability index to patient geographies based on ZIP codes.
Utilized Kaplan-Meier and Cox proportional hazards models to assess survival and treatment outcomes.
High area deprivation index associated with worse survival (median 2 months) compared to low area deprivation index (median 4 months).
Lower chemotherapy rates in high area deprivation index patients (48.3% vs 51.5%).
Bone marrow transplantation less common in high area deprivation index group (11.5% vs 15.2%).
Increased ICU admissions and hospice use linked to high area deprivation index, especially in terminal stages.

Cite This Study

Tran et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf89 https://doi.org/10.1182/blood-2025-2847

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Implication

Population-based study shows area deprivation index predicts worse survival and treatment disparities in older adults with acute myeloid leukemia, indicating socioeconomic factors impact care.

Area deprivation index as a predictor of survival and treatment disparities in older adults with Acute Myeloid Leukemia: A population-based Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Area deprivation index as a predictor of survival and treatment disparities in older adults with Acute Myeloid Leukemia: A population-based Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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