What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

This research aims to compare clonal evolution and genomic profiles in minor versus major BCR::ABL1 chronic myeloid leukemia during treatment.

December 8, 2025Blood

Molecular landscape and clonal evolution in minor versus major BCR::ABL1 chronic myeloid leukemia under tyrosine kinase inhibition : A Study from the french group fi-LMC

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Authors

BPBenjamin PodvinInserm SHSandrine HayetteHospices Civils de Lyon VCValérie CoiteuxUniversité de Lille

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Implication

Observational study reveals distinct clinical and genomic profiles in minor BCR::ABL1 CML compared to major type, highlighting treatment implications.

Key Points

This research aims to compare clonal evolution and genomic profiles in minor versus major BCR::ABL1 chronic myeloid leukemia during treatment.
Identified 42 patients with p190 CML, matched to age-matched 42 p210 CML patients.
Conducted genomic profiling and complete blood counts at diagnosis and follow-up.
Analyzed mutations and cytogenetic abnormalities using targeted high-throughput sequencing.
CML patients with p190 showed higher mutation rates compared to p210 patients (88% vs 22%).
Complete blood counts showed significantly lower white blood and platelet counts in p190 patients.
A subset of p190 patients exhibited chronic myelomonocytic leukemia-like features with co-mutations.

Cite This Study

Podvin et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfe8 https://doi.org/10.1182/blood-2025-77

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Implication

Observational study reveals distinct clinical and genomic profiles in minor BCR::ABL1 CML compared to major type, highlighting treatment implications.

Molecular landscape and clonal evolution in minor versus major BCR::ABL1 chronic myeloid leukemia under tyrosine kinase inhibition : A Study from the french group fi-LMC

Discussion

Member takes

Implication

Key Points

Cite This Study

Molecular landscape and clonal evolution in minor versus major BCR::ABL1 chronic myeloid leukemia under tyrosine kinase inhibition : A Study from the french group fi-LMC

Discussion

Member takes

Implication

Key Points

Cite This Study

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