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December 8, 2025Blood

Combined factor v and VIII deficiency: A mucocutaneous bleeding phenotype driven predominantly by factor VIII – a retrospective study of 34 patients

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Authors

ATAnusha ThangarajaRDRutvi Gautam DaveRLR. Lawrence

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Overview

Retrospective study shows factor VIII predicts bleeding severity in patients with combined factor V and VIII deficiency, indicating unique clinical features.

Key Points

  • To evaluate the bleeding phenotype and predictors of severity in F5F8D, focusing on FV and FVIII levels.
  • Retrospective cohort study over 10 years at a tertiary care center.
  • Inclusion of patients diagnosed with F5F8D through factor assays with clinical records.
  • Assessment of bleeding phenotype using ISTH-BAT and measurement of factor levels via standard assays.
  • 34 patients had mucocutaneous bleeding, with prolonged bleeding from minor wounds in 47%.
  • Factor VIII levels showed a moderate inverse correlation with ISTH-BAT scores, predicting bleeding severity.
  • No joint bleeding observed even at low FVIII levels, indicating a distinct phenotype compared to hemophilia A.

Cite This Study

Thangaraja et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cff8https://doi.org/10.1182/blood-2025-312
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rare Coagulopathies in Hematologic Spotlight: Isolated Factor V Deficiency and Combined Factor V and VIII Deficiency2024
  2. 2Genetic and Laboratory Predictors of Bleeding Severity in FVII Deficiency: Insights from PRO-RBDD and EN-RBD Databases2026
  3. 3445 Hemophilia A: when the bleeding patient looks worse than lab testing would indicate2025
  4. 4Usefulness of Global Coagulation Tests, Thrombin Generation and Viscoelastic Tests for Assessing the Bleeding Phenotype in Rare Coagulation Factor Deficiencies2025 · 3 citations
  5. 5Mild Congenital Factor V11 FV11 Deficiency Presenting with Recurrent Minor TraumaRelated Bleeding in a Toddler A Rare Case Report and Mini Review2026