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October 17, 2025Hämostaseologie

Usefulness of Global Coagulation Tests, Thrombin Generation and Viscoelastic Tests for Assessing the Bleeding Phenotype in Rare Coagulation Factor Deficiencies

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Authors

TDTorsten DreierDMDino MehicJGJohanna Gebhart

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Overview

Review assesses bleeding severity using thrombin generation and viscoelastic tests in rare coagulation deficiencies, indicating potential management strategies.

Key Points

  • Thrombin generation and ROTEM were impaired in most rare coagulation factor deficiencies, linking them to bleeding severity.
  • Significantly reduced coagulation factor activity correlated with greater clinical bleeding severity in multiple deficiencies.
  • PGA showed variable impairment but did not reliably predict bleeding manifestations, limiting its clinical utility.
  • ROTEM effectively discriminated between asymptomatic and bleeding history patients with specific coagulation deficiencies.

Cite This Study

Dreier et al. (2025) studied this question.

synapsesocial.com/papers/68f199ccde32064e504dd1c6https://doi.org/10.1055/a-2651-8816
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