Key result
Thrombin generation assay parameters (lag time, time to peak, and start tail) significantly correlated with bleeding score (P < .05) and yielded a negative predictive value of 86% to 90%.
Why the study?
Does the thrombin generation assay improve the prediction of bleeding risk compared to conventional coagulation tests in patients with rare bleeding disorders?
Population
83 patients with rare bleeding disorders (RBDs) in southern Iran
Comparison
Thrombin generation (TG) assay vs Conventional coagulation tests including…
Design
Cross-sectional
Authors
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Thrombin generation parameters were associated with bleeding scores in rare disorders; hypothesis-generating and requires prospective validation before clinical adoption.
Cross-Sectional (n=83)
No
Does the thrombin generation assay improve the prediction of bleeding risk compared to conventional coagulation tests in patients with rare bleeding disorders?
p-value: p=< .05
The thrombin generation assay is a potentially more useful tool than conventional coagulation tests for predicting bleeding risk in patients with rare bleeding disorders.
Zekavat et al. (2013) conducted a cross-sectional in Rare bleeding disorders (RBDs) (n=83). Thrombin generation (TG) assay vs. Conventional tests (PT and aPTT) was evaluated on Bleeding risk (bleeding score) (p=< .05). Thrombin generation assay parameters (lag time, time to peak, and start tail) significantly correlated with bleeding score (P < .05) and yielded a negative predictive value of 86% to 90%.
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