What question did this study set out to answer?

To discuss and identify the most rational and clinically effective coagulation monitoring modalities for future studies and perioperative bleeding management.

April 10, 2009British Journal of AnaesthesiaOpen Access

Coagulation tests in future studies: what to use?

View Full Paper

Ask AI

Bookmark

Authors

PMP MoorCambridge Military Hospital TWTom WoolleyRoyal Navy MMMark J. MidwinterThe University of Queensland

Discussion

Member takes

Implication

Editorial correspondence demonstrates point-of-care viscoelastic testing outperforms standard plasma assays during massive haemorrhage, indicating superior guidance for targeted blood component...

Key Points

To discuss and identify the most rational and clinically effective coagulation monitoring modalities for future studies and perioperative bleeding management.
Expert scientific exchange evaluating standard laboratory plasma assays (prothrombin time, activated partial thromboplastin time, Clauss fibrinogen assay) versus point-of-care whole blood viscoelastic testing (ROTEM and TEG).
Analysis of diagnostic limitations caused by colloid plasma expanders, hemodilution, and acquired hypofibrinogenemia in the setting of massive hemorrhage.
Standard plasma coagulation tests and Clauss fibrinogen assays can yield falsely elevated or misleading values in the presence of colloid expanders or breakdown products.
Whole blood viscoelastic assays (ROTEM and TEG, including FibTEM) rapidly differentiate between factor depletion, thrombocytopenia, abnormal fibrin polymerization, and hyperfibrinolysis.
Bedside viscoelastic testing provides superior real-time guidance for targeted fibrinogen concentrate substitution and reduces unnecessary donor blood component exposure.

Cite This Study

Moor et al. (2009) studied this question.

synapsesocial.com/papers/6a945f6b175d68f85fc57da5 https://doi.org/10.1093/bja/aep070

View Full Paper

Ask AI

Bookmark

Implication

Editorial correspondence demonstrates point-of-care viscoelastic testing outperforms standard plasma assays during massive haemorrhage, indicating superior guidance for targeted blood component...

Coagulation tests in future studies: what to use?

Discussion

Member takes

Implication

Key Points

Cite This Study

Coagulation tests in future studies: what to use?

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider