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December 8, 2025BloodOpen Access

Adrenergic signaling and hematopoietic stem cell function in the bone marrow niche rely on peri-arteriolar NADPH oxidase (NOX) and connexin gap junctions.

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Authors

FLFrancesca LicausiDZDachuan ZhangMMMaria Maryanovich

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Overview

Findings reveal adrenergic signaling modulates HSC function in the bone marrow niche, suggesting novel therapeutic avenues.

Key Points

  • This research investigates how adrenergic signaling influences hematopoietic stem cell function via the bone marrow microenvironment.
  • Studied hematopoietic stem cells within bone marrow niches in mice models.
  • Utilized sympathectomy and genetic deletion strategies to examine receptor roles.
  • Developed a co-culture system to investigate stromal communication and signaling mechanisms.
  • Identified connections between β-adrenergic receptors, NADPH oxidase, and connexin in regulating HSC function.
  • Demonstrated oscillations of superoxide in reticular MSCs affected by adrenergic signalling reduction.
  • Showed that loss of NOX or connexin led to changes in MSC behavior and HSC engraftment outcomes.

Cite This Study

Licausi et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d002https://doi.org/10.1182/blood-2025-427
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Revisiting MSC heterogeneity: significance of the CD73+CD39+CD146+ perivascular subset in bone marrow2026
  2. 2Endothelial SRSF1 regulates hematopoietic stem cell function in the bone marrow microenvironment2025
  3. 3Spatial transcriptomics identified dynamic and spatial-resolved niche cell and signal architecture for hematopoietic stem cell specification2025
  4. 4Bone marrow microenvironment retinoic acid receptor signaling represses multipotential progenitor dependent B cell lymphopoiesis through secretion of resistin2025
  5. 5Defect in Migration of HSPCs in Nox-2 Deficient Mice Explained by Impaired Activation of Nlrp3 Inflammasome and Impaired Formation of Membrane Lipid Rafts2024 · 8 citations