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December 8, 2025Blood

Real-World Effectiveness and Resource Utilization of Red Blood Cell Exchange in Adult Sickle Cell Disease: a Nationwide Robust Analysis from 2017-2022

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Authors

BABenedict AmalrajAKAnil KumarMCMariana Marrero Castillo

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Overview

Retrospective analysis reveals RBC exchange increases hospitalization duration and resource utilization in sickle cell disease patients.

Key Points

  • Evaluate the clinical effectiveness and resource utilization of red blood cell exchange in hospitalized adults with sickle cell disease.
  • Conducted a retrospective cohort study using the Healthcare Cost and Utilization Project National Inpatient Sample from 2017 to 2022.
  • Included adult hospitalizations with a diagnosis of sickle cell disease using specific ICD codes.
  • Applied propensity score and doubly robust estimation to control for confounding variables.
  • Over 926,000 hospitalizations for sickle cell disease were analyzed, with red blood cell exchange performed in 2,775 cases.
  • RBC exchange did not significantly reduce in-hospital mortality (adjusted Odds Ratio 1.36).
  • Patients undergoing RBC exchange had 45% longer hospital stays and 84% higher total charges.

Cite This Study

Amalraj et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d03ahttps://doi.org/10.1182/blood-2025-7968
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