Analysis demonstrates changes in sepsis-specific mortality rates in adults with multiple myeloma, highlighting disparities among rural areas and certain demographics.
Key Points
This research evaluates sepsis-specific mortality trends among U.S. adults with multiple myeloma over 24 years.
Analyzed CDC WONDER Multiple Cause of Death data from 1999 to 2023.
Calculated age-adjusted mortality rates using U.S. standard population.
Employed Joinpoint regression for temporal trend analysis.
Stratified analyses by age, sex, residence, and year.
29,612 sepsis-related deaths recorded among U.S. adults with multiple myeloma.
While overall mortality rates declined, absolute deaths increased from 973 in 1999 to 1,411 in 2022.
Female mortality declined steadily, while male rates showed variability.
Significant disparities emerged among older adults, rural residents, and specific regions.