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December 8, 2025Blood

Trends and disparities in hematologic malignancy and sepsis-related mortality in adults aged ≥ 65 years in the United States from 1999 to2023: A CDC wonder database analysis

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Authors

ANAmmar NasirAMAli MuhammadAKAmal Khan

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Overview

Analysis of mortality trends in adults ≥ 65 with hematologic malignancy and sepsis, showing significant disparities across age groups and race.

Key Points

  • To examine long-term trends in hematologic malignancy and sepsis-related mortality in adults aged ≥ 65 years in the US from 1999 to 2023.
  • Used CDC WONDER Multiple Cause-of-Death dataset for mortality analysis.
  • Analyzed ICD-10 codes for hematologic malignancy and sepsis.
  • Calculated age-adjusted mortality rates and annual percent changes.
  • Stratified results by demographics and geography.
  • Total of 110,426 deaths from hematologic malignancy and sepsis in adults ≥ 65 years (1999-2023).
  • Overall age-adjusted mortality rates declined but varied significantly by age and race.
  • Men had higher mortality rates than women, with women showing a greater decline.
  • Non-Hispanic Black Americans had the highest mortality rates, but rates for this group declined.

Cite This Study

Nasir et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1a5https://doi.org/10.1182/blood-2025-2860
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