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December 8, 2025BloodOpen Access

Acute Myeloid Leukemia and sepsis-related mortality in the United States (U.S.) older adults: Nationwide trends and disparities over 25 years (1999 – 2023)

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Authors

HTHareem Tahir

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Overview

Analysis reveals rising sepsis-related mortality trends in older adults with AML, highlighting significant disparities by age and race.

Key Points

  • Evaluate long-term trends in sepsis-related mortality among older adults with acute myeloid leukemia in the U.S.
  • Extracted mortality data from the CDC WONDER database
  • Focused on adults aged ≥ 55 from 1999 to 2023
  • Analyzed using ICD-10 codes for AML and sepsis
  • Calculated age-adjusted mortality rates and annual percentage changes
  • Conducted subgroup analysis based on age, sex, and race/ethnicity.
  • Total of 28888 deaths reported from 1999 to 2023 in adults aged ≥ 18
  • Older adults (≥ 55) had an average AAMR of 1.16, showing an increase over the years
  • Significant rise in AAMR in males aged ≥ 55 compared to females
  • Racial disparities noted among non-Hispanic Whites, with the highest AAMR of 1.19
  • Increased mortality trends particularly pronounced in NH Black/African American individuals.

Cite This Study

Hareem Tahir (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e458https://doi.org/10.1182/blood-2025-1627
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends in sepsis-related mortality among patients with Acute Myeloid Leukemia: A 24-year nationwide analysis2025
  2. 2Acute Myeloid Leukemia mortality in u.S. older adults: A 45-year nationwide analysis with forecasting through 20502025
  3. 3Trends and disparities in hematologic malignancy and sepsis-related mortality in adults aged ≥ 65 years in the United States from 1999 to2023: A CDC wonder database analysis2025
  4. 4A dangerous convergence: Long-term mortality trends in aplastic anemia and sepsis (1999-2023)2025
  5. 5Changing burden of Acute Myeloid Leukemia in the United States: A 23-year national analysis2025