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December 8, 2025BloodOpen Access

A dangerous convergence: Long-term mortality trends in aplastic anemia and sepsis (1999-2023)

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Authors

NZNafila ZeeshanSGSwapna GangasaniSMS Mayet

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Overview

Analysis of mortality rates from aplastic anemia and sepsis in diverse groups shows significant disparities.

Key Points

  • This research aims to characterize long-term mortality trends in aplastic anemia and sepsis and their disparities.
  • Retrospective analysis using CDC WONDER database data from 1999-2023.
  • Calculation of age-adjusted mortality rates (AAMRs) per 100,000 persons.
  • Assessment of trends using Average Annual Percentage Change (AAPC) and Annual Percent Change (APC).
  • Data stratification by race/ethnicity and geographical regions.
  • Total of 140,846 AA-related deaths recorded from 1999 to 2023.
  • National AAMR rose from 2.23 (1999) to 3.33 (2023), with three distinct trend phases.
  • Males had higher AAMRs (2.76) compared to females (2.29), with increasing trends in both sexes.
  • African Americans exhibited the highest AAMR (4.85), while older adults had the highest AAMR overall (9.36).
  • Regional disparities were noted, with the South demonstrating the highest AAMR (2.85) and significant increases in the West.

Cite This Study

Zeeshan et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d18chttps://doi.org/10.1182/blood-2025-6453
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