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December 8, 2025Blood

Aplastic anemia mortality in the United States (1999–2023): Trends, disparities, and public health implications

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Authors

SKSaad KhanMMMadho MalYKYury Kachynski

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Overview

Retrospective analysis reveals rising aplastic anemia mortality trends and racial disparities, indicating urgent need for targeted interventions.

Key Points

  • To analyze mortality trends and disparities in aplastic anemia-related deaths in the US from 1999 to 2023.
  • Conducted a retrospective population-based analysis of aplastic anemia-related mortality data from 1999 to 2023.
  • Calculated age-adjusted mortality rates stratified by sex, race/ethnicity, and geographic region.
  • Assessed temporal trends using joinpoint regression analysis.
  • A total of 130,437 aplastic anemia-related deaths occurred from 1999 to 2023.
  • The age-adjusted mortality rate showed a decline from 1999 to 2015, followed by an increase from 2015 to 2023.
  • Significant racial disparities were noted, with American Indians experiencing the highest age-adjusted mortality rate.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd1dhttps://doi.org/10.1182/blood-2025-7996
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Temporal trends in aplastic anemia mortality across u.S. regions (1999–2020)2025
  2. 2Mortality patterns due to aplastic anemia in the United States: A retrospective analysis from 1999 to 20232025
  3. 3Aplastic anemia and substance use: National trends and associations in the United States from 1999-2023- a CDC wonder analysis2025
  4. 4The constant burden-aplastic anaemia as the underlying cause of death in older US adults- half century insights from the CDC wonder database (1968-2023)2025
  5. 5A dangerous convergence: Long-term mortality trends in aplastic anemia and sepsis (1999-2023)2025