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December 8, 2025BloodOpen Access

Mortality patterns due to aplastic anemia in the United States: A retrospective analysis from 1999 to 2023

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AAAmna AmjadAMAleksandr Markov

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Overview

Retrospective analysis reveals rising mortality in aplastic anemia, particularly among males and Black individuals, indicating health inequities.

Key Points

  • The study aims to characterize trends and identify disparities in aplastic anemia-related mortality across the United States from 1999 to 2023.
  • Retrospective analysis using CDC WONDER Multiple Cause of Death data
  • Calculated crude mortality rates and age-adjusted mortality rates per 100,000 people
  • Analyzed temporal trends with Joinpoint regression for annual percent change and average annual percent change
  • Among 131,548 AA-related deaths from 1999 to 2023, AAMR increased from 2.51 to 2.85
  • Males had higher mortality than females (AAMR: 2.89 vs. 1.96)
  • Black individuals had the highest mortality (AAMR: 2.50), followed by White, Hispanic, and Asian/Pacific Islander populations
  • The Midwest had the highest AAMR (2.49), with rural areas showing notably higher mortality than metropolitan regions (AAMR: 2.63 vs. 2.23)

Cite This Study

Amjad et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2abhttps://doi.org/10.1182/blood-2025-6460
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