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December 8, 2025BloodOpen Access

The constant burden-aplastic anaemia as the underlying cause of death in older US adults- half century insights from the CDC wonder database (1968-2023)

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Authors

AUAman UllahSBSyed BukhariFAFatima Binte Athar

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Overview

Analysis reveals declining mortality rates from aplastic anemia in older adults, indicating progress in hematopoietic stem cell therapies and interventions for high-risk groups.

Key Points

  • This work investigates the mortality burden of aplastic anemia in older US adults from 1968 to 2023.
  • Analyzed mortality rates using CDC WONDER database
  • Employed ICD-10 codes for identifying aplastic anemia cases
  • Utilized Joinpoint regression for estimating Annual Percent Change
  • Aplastic anemia caused 57,679 deaths from 1968 to 2023
  • Overall age-adjusted mortality rate declined from 10.3 to 3.7 per 100,000
  • Men had higher mortality rates than women, with notable declines

Cite This Study

Ullah et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236e06fhttps://doi.org/10.1182/blood-2025-6726
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Temporal trends in aplastic anemia mortality across u.S. regions (1999–2020)2025
  2. 2Aplastic anemia and substance use: National trends and associations in the United States from 1999-2023- a CDC wonder analysis2025
  3. 3Mortality patterns due to aplastic anemia in the United States: A retrospective analysis from 1999 to 20232025
  4. 4Aplastic anemia mortality in the United States (1999–2023): Trends, disparities, and public health implications2025
  5. 5A dangerous convergence: Long-term mortality trends in aplastic anemia and sepsis (1999-2023)2025