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December 8, 2025BloodOpen Access

Trends in sepsis-related mortality among patients with Acute Myeloid Leukemia: A 24-year nationwide analysis

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Authors

OSOjasav Sehrawat

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Overview

Population-based study reveals increased mortality rates in older age groups with sepsis among AML patients, highlighting healthcare disparities.

Key Points

  • To analyze trends in sepsis-related mortality among patients with acute myeloid leukemia over 24 years.
  • Retrospective, population-based study using CDC WONDER mortality data from 1999-2023.
  • Identified sepsis-related deaths using ICD-10 codes.
  • Analyzed demographics including age, sex, region, and urbanization.
  • Calculated age-adjusted mortality rates (AAMRs) and trends through Joinpoint regression.
  • Identified 27,328 sepsis-related deaths among AML patients.
  • Highest mortality observed in the 65-74 age group (30.8%).
  • Mortality rates rose significantly in older age groups until 2018-2019, with a decline afterward.
  • Notable geographic variations in mortality trends and existing healthcare disparities.

Cite This Study

Ojasav Sehrawat (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d66bhttps://doi.org/10.1182/blood-2025-5164
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute Myeloid Leukemia and sepsis-related mortality in the United States (U.S.) older adults: Nationwide trends and disparities over 25 years (1999 – 2023)2025
  2. 2Mortality trends of sepsis in patients with leukemia in the United States (1999–2020): A CDC wonder database analysis2025
  3. 3National trends in sepsis-related mortality among decedents with malignant neoplasms in the United States, 1999–2023.2026
  4. 4Trends in sepsis-related mortality among adults with cancer aged ≥ 25 years in United States, 1999-2020: A CDC WONDER study.2026
  5. 5A dangerous convergence: Long-term mortality trends in aplastic anemia and sepsis (1999-2023)2025