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December 8, 2025BloodOpen Access

Acute Myeloid Leukemia mortality in u.S. older adults: A 45-year nationwide analysis with forecasting through 2050

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SDSafi Ur Rehman Daim

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Overview

Analysis shows significant mortality trends in older adults with AML, indicating need for improved interventions.

Key Points

  • This analysis evaluates mortality trends in acute myeloid leukemia among older adults in the U.S.
  • Evaluated mortality trends from 1979 to 2023 in adults aged ≥65 years
  • Identified AML-related deaths using ICD-10 code
  • Calculated age-adjusted mortality rates and used Joinpoint regression for trend analysis
  • Developed forecasting models for mortality through 2050
  • 224,418 AML-related deaths occurred from 1979 to 2023 in older adults
  • Overall age-adjusted mortality rate increased from 107.8 to 149.2 per million
  • Males had higher mortality rates than females; regionally, Midwest had the highest rates
  • Forecasting models predict a rise to 191.4 per million by 2050, highlighting ongoing health disparities

Cite This Study

Safi Ur Rehman Daim (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e45chttps://doi.org/10.1182/blood-2025-1633
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changing burden of Acute Myeloid Leukemia in the United States: A 23-year national analysis2025
  2. 2Acute Myeloid Leukemia and sepsis-related mortality in the United States (U.S.) older adults: Nationwide trends and disparities over 25 years (1999 – 2023)2025
  3. 3Comparative analysis of mortality trends in acute versus chronic myeloid leukemia in the U.S. population with time series projection: A CDC WONDER–based study (1999–2023).2026
  4. 4Temporal trends and demographic disparities in myelodysplastic syndrome-associated mortality in Acute Myeloid Leukemia patients in the United States: A population-based analysis (1999–2023)2025
  5. 5Trends in Acute Myeloid Leukemia mortality among patients with myelodysplastic syndrome in the United States (1999–2024): A CDC wonder database analysis2025